macrogametocytes, go through some morphological changes that form macrogametes that eventually differentiate into receptive cones. Thus, the blood sucked by the Anopheles mosquito will primarily enter the mid-gut and later move towards the salivary gland. During the sexual reproduction of the malaria parasite (Plasmodium), the gametocytes of the infected person’s blood will further differentiate and undergo fertilization to form a zygote in a female Anopheles mosquito’s stomach. Once a female Anopheles sucks the blood of an infected person, the gametocytes will further differentiate in the mid-gut of the mosquito, and there the sexual reproduction of the Plasmodium begins. Macrogametocytes and microgametocytes will remain in the bloodstream of an infected person. It comprises of a small peripheral nucleus The characteristic difference between the macrogametocytes and microgametocytes of Plasmodium is given below in the table. Thus, the merozoites will form gametocytes instead of schizonts after several generations of erythrocytic schizogony. The merozoites in the bloodstream will differentiate into two distinct gametocytes, namely macrogametocytes and microgametocytes. The lysis of RBC occurs at the end of the erythrocytic phase once a cell becomes laden with enough merozoites. A rosette stage appears at the end of the erythrocytic phase, where the merozoites shift towards the RBCs’ periphery. We could observe schuffner cells and haemozoin granules (deposits of haematin) during the merozoite stage. Then, the amoeboid stage transforms into erythrocytic schizont, which further undergoes cell division to form merozoites. The trophozoite wall becomes irregular during an amoeboid stage, resulting in the complete breakdown of haemoglobin content into haematin and globin. Later, an amoeboid stage replaces the signet ring stage. A signet ring stage occurs, in which a trophozoite increases its size and forms a large non-contractile vacuole. haemoglobin, to form a trophozoite.Ī trophozoite goes through various morphological changes, which we can see in the above picture. Once the merozoites enter into the RBC, they will start utilizing the content of RBC, i.e. The metacryptomerozoites will penetrate the wall of RBCs through the activity of hydrolytic enzymes. In this stage, the metacryptomerozoites or merozoites will infect the erythrocytes. Ultimately, a liver cell laden with a large number of metacryptomerozoites will burst out, and it will release all the infectious particles into the bloodstream.Schizonts will divide and grow in number to produce metacryptomerozoites.They will then invade the nutrients and other essential components of the hepatic cells to form a schizont.The cryptometazoites will again penetrate the wall of new hepatic cells.Exoerythrocytic schizogony involves the following morphological changes. Here, the cryptometazoites released from a liver cell will infect other new liver cells. It is a stage before the infection of RBCs. Eventually, a hepatic cell becomes laden with the numerous cryptometazoites, and it will burst out, resulting in the release of cryptometazoites.The cryptozoites will again increase their size and number to produce cryptometazoites.After that, a schizont will divide to increase its number and form cryptozoites.The sporozoites that attained a large size are called schizonts. Then, the sporozoites harness the liver cells’ essential components to nourish themselves.Firstly, the sporozoites released from the female Anopheles mosquito’s salivary gland will penetrate the hepatic cell wall through some lysosomal enzymes.It involves a series of morphological changes that are discussed below: This stage can be defined as the infection phase of the liver cells. The sporozoites then find out their way to infect the liver cells. It is the stage when the sporozoites enter the bloodstream via a mosquito bite. The asexual lifecycle of Plasmodium involves five stages: Plasmodium species lack locomotary organs but move through the bloodstream from one host to the other. Plasmodium species are endoparasites which infect and reside within the host cells. The sexual life cycle of Plasmodium is called sporogony, whereas the asexual life cycle of Plasmodium is called schizogony. malariae, where all the species cause four distinct types of malaria. Plasmodium is a malaria parasite that generally includes four species, P. Content: Life Cycle of Plasmodium Species Here, you will get to know the elaborative study of the asexual and sexual stages in the Plasmodium’s life cycle. Its sexual phase is anisogamous, and the asexual phase occurs through binary fission.
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